GLGC, Global Lipids Genetics Consortium; HDL, high-density lipoprotein;
HERMES, Heart Failure Molecular Epidemiology for Therapeutic Targets;
ICBP, International Consortium of Blood Pressure; LDL, low-density
lipoprotein; MAGIC, Meta-Analyses of Glucose and Insulin-related traits
Consortium; NA, not available; UK Biobank, UKBB.
*The genetic association summary statistics estimates were extracted
from the MR-Base platform11, publicly available
genetic consortia data, or the last public release (R4) of the FinnGen
consortium.16
†Estimated nutrient intake based on UKBB participants’ answers to the
dietary questionnaire.
‡Three independent consortia, including Alzheimer’s disease working
group of the Psychiatric Genomics Consortium (PGC-ALZ), the
International Genomics of Alzheimer’s Project (IGAP), and the
Alzheimer’s Disease Sequencing Project (ADSP).
§The dataset consists of 24 087 clinically diagnosed late-onset
Alzheimer’s disease cases, paired with 55 058 controls plus the
AD-by-proxy phenotype, based on individuals in the UK Biobank (UKB) for
whom parental Alzheimer’s disease status was available (proxy
cases = 47 793; proxy controls = 328 320).