Methods
All data used for this work are publicly available, as detailed below. Circulating FGF21 concentration was proxied by a genetic variant (rs838133) in the FGF21 gene region, previously shown to be associated with fasting plasma FGF219 as well as with intake of macronutrients, alcohol and sweets.6, 9Publicly available summary-level data for the associations of the FGF21 variant with macronutrient and alcohol intake and other outcomes were obtained from UK Biobank and genome-wide association study consortia. Details of the outcome datasets used in this study are provided in Table 1.