GLGC, Global Lipids Genetics Consortium; HDL, high-density lipoprotein; HERMES, Heart Failure Molecular Epidemiology for Therapeutic Targets; ICBP, International Consortium of Blood Pressure; LDL, low-density lipoprotein; MAGIC, Meta-Analyses of Glucose and Insulin-related traits Consortium; NA, not available; UK Biobank, UKBB.
*The genetic association summary statistics estimates were extracted from the MR-Base platform11, publicly available genetic consortia data, or the last public release (R4) of the FinnGen consortium.16
†Estimated nutrient intake based on UKBB participants’ answers to the dietary questionnaire.
‡Three independent consortia, including Alzheimer’s disease working group of the Psychiatric Genomics Consortium (PGC-ALZ), the International Genomics of Alzheimer’s Project (IGAP), and the Alzheimer’s Disease Sequencing Project (ADSP).
§The dataset consists of 24 087 clinically diagnosed late-onset Alzheimer’s disease cases, paired with 55 058 controls plus the AD-by-proxy phenotype, based on individuals in the UK Biobank (UKB) for whom parental Alzheimer’s disease status was available (proxy cases = 47 793; proxy controls = 328 320).