Methods
All data used for this work are publicly available, as detailed below.
Circulating FGF21 concentration was proxied by a genetic variant
(rs838133) in the FGF21 gene region, previously shown to be
associated with fasting plasma FGF219 as well as with
intake of macronutrients, alcohol and sweets.6, 9Publicly available summary-level data for the associations of the FGF21
variant with macronutrient and alcohol intake and other outcomes were
obtained from UK Biobank and genome-wide association study consortia.
Details of the outcome datasets used in this study are provided in Table
1.