GLGC, Global Lipids Genetics Consortium; HDL, high-density lipoprotein; HERMES, Heart Failure Molecular Epidemiology for Therapeutic Targets; ICBP, International Consortium of Blood Pressure; LDL, low-density lipoprotein; MAGIC, Meta-Analyses of Glucose and Insulin-related traits Consortium; NA, not available; UK Biobank, UKBB.

*The genetic association summary statistics estimates were extracted from the MR-Base platform¹¹, publicly available genetic consortia data, or the last public release (R4) of the FinnGen consortium.¹⁶

†Estimated nutrient intake based on UKBB participants’ answers to the dietary questionnaire.

‡Three independent consortia, including Alzheimer’s disease working group of the Psychiatric Genomics Consortium (PGC-ALZ), the International Genomics of Alzheimer’s Project (IGAP), and the Alzheimer’s Disease Sequencing Project (ADSP).

§The dataset consists of 24 087 clinically diagnosed late-onset Alzheimer’s disease cases, paired with 55 058 controls plus the AD-by-proxy phenotype, based on individuals in the UK Biobank (UKB) for whom parental Alzheimer’s disease status was available (proxy cases = 47 793; proxy controls = 328 320).