Authors’ contributions
C.J.T., M.Ab., T.R. and N.Ba. designed the study. CJT, M.An., S.S., K.P. performed the experiments. A.D., K.P., F.S.S., O.W., T.H.W. recruited patients. C.J.T., M.Ab, T.R. and N.Ba. analysed the data. C.J.T., M.Ab., E.F. and N.Ba. wrote the manuscript. M.An., N.Br., U.S., G.H., M.E reviewed and edited the manuscript. N.Br. supervised the project. All authors discussed the results and commented on the manuscript.