loading page

Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy
  • +7
  • Jon Genuneit,
  • Sashini Jayasinghe,
  • Rachel Peters,
  • Derek Chu,
  • Daniel Munblit,
  • Robert Boyle,
  • George Du Toit,
  • Isabel Skypala,
  • Alexandra Santos
Jon Genuneit
Leipzig University

Corresponding Author:jon.genuneit@medizin.uni-leipzig.de

Author Profile
Sashini Jayasinghe
King's College London
Author Profile
Fundacion Sant Joan de Deu
Author Profile
Rachel Peters
Murdoch Childrens Research Institute
Author Profile
Derek Chu
McMaster University
Author Profile
Daniel Munblit
Imperial College London
Author Profile
Robert Boyle
Imperial College
Author Profile
George Du Toit
King's College London
Author Profile
Isabel Skypala
Royal Brompton & Harefield NHS Trust
Author Profile
Alexandra Santos
King's College London
Author Profile


Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of updating the guidelines on the diagnosis and management of food allergy. The existing guidelines are based on a systematic review of the literature until 30th September 2012. Therefore, a new systematic review must be undertaken to inform the new guidelines. This systematic review aims to assess the accuracy of index tests to support the diagnosis of IgE-mediated food allergy. Methods: The databases Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID) will be searched for diagnostic test accuracy studies from 1st October 2012 to 30th June 2021. Inclusion and exclusion criteria will be used to select appropriate studies. Data from these studies will be extracted and tabulated, and then reviewed for risk of bias and applicability using the QUADAS-2 tool. All evaluation will be done in duplicate. Studies with a high risk of bias and low applicability will be excluded. Meta-analysis will be performed if there are three or more studies of the same index test and food. Results: A protocol for the systematic review and meta-analyses is presented and was registered using Prospero prior to commencing the literature search. Discussion: Oral food challenges are the reference standard for diagnosis but involve considerable risks and resources. This protocol for systematic review aims to assess the accuracy of various tests to diagnose food allergy, which can be useful in both clinical and research settings.
08 Jul 2021Submitted to Pediatric Allergy and Immunology
20 Jul 2021Review(s) Completed, Editorial Evaluation Pending
20 Jul 2021Reviewer(s) Assigned
09 Aug 2021Editorial Decision: Revise Minor
06 Sep 20211st Revision Received
07 Sep 2021Review(s) Completed, Editorial Evaluation Pending
09 Sep 2021Editorial Decision: Accept
Jan 2022Published in Pediatric Allergy and Immunology volume 33 issue 1. 10.1111/pai.13684