Limitations
There were limitations in the present study. Patients with severe
cardiac diseases and noncardiac death were excluded from our study,
which had some degree of selection bias. The 3D RV endocardial border
identification may be of challenge as echo dropouts frequently occur.
Due to the small size of our study, we did not confirm the finding in a
separate independent “validation cohort”. The development and
validation of a multivariable prediction model for CAE after R-CHOP
regimens treatment among patients with lymphoma is required in our
future studies. Separate multivariable Cox analysis may be overfitted
owing to the low incidence of adverse cardiac events induced by
chemotherapy. Finally, our patients didn’t undergo cardiac magnetic
resonance (CMR) so our RV data sets measured by 3D transthoracic
echocardiography were not tested for the correlation with CMR.