Statistical analysis
Continuous data are expressed as the mean ± SD. Categorical variables
were expressed as counts (percentages). Kolmogorov-Smirnov Z tests were
used to evaluate the normality of the data. Parametric tests were
applied when normality was satisfied, otherwise, the Mann-Whitney U
tests and chi-square tests were used for nonparametric data. Time to
first CAE was defined as the number of days between the start of
anthracycline therapy and the date of the first CAE and was considered
for survival analysis. Patients who had not experienced CAEs as of their
last visit date were censored at this date. Cox proportional hazard
analysis was used to determine significant clinical and
echocardiographic identifiers of time to CAEs. To perform a comparison
of RVEF and LVGLS, we performed a proportional hazard analysis using
these two terms in a multivariate analysis. The incremental value of
RVEF and LVGLS compared with RVEF in identifying subsequent CAEs was
tested with chi-square tests. Receiver operating characteristic curve
analysis was used to determine the relationship of LVGLS and RVEF value
to the occurrence of CAEs. Survival without CAEs as a function of RVEF
was analyzed using Kaplan-Meier analysis. All analyses were performed
using a standard statistical software program (IBM SPSS Statistics for
Windows version 23.0; IBM, Armonk, NY). P values < .05 were
considered to indicate statistical significance.