Methods
The study was designed to consist of sixteen Wistar albino rats, their
right ears being the control group and left ears being the experiment
group. %50 propylene glycol, gentamicinsulfate and physiologic salt
water were applied to the right ear and %50 propylene glycol,
gentamicinsulfate and %20 Mesna were administered to the left ear
through intratympanic injections on days 1, 3, 8, 15 and 21. The rats
were sacrificed 45 days after the first injection and underwent
histopathological examination.