Figure 2
Figure 2. Schematic representation of SARS-CoV-2 entry and replication in host cells. SARS-CoV-2 enters host cells through its spike ‘S’ protein by interacting with host’s ACE-2 receptor where S is primed by the host cell serine protease, TMPRSS2. Upon entry, release of viral genomic RNA subsequently leads to genomic replication by using host cell’s translational and transcriptional machineries. Structural proteins are synthesized and assembled at Endoplasmic reticulum (ER) and Golgi apparatus (GA) respectively, followed by their maturation and release.