What’s already known about this topic?
The KIM-1 molecule, which was previously associated with acute kidney
damage, is synthesized in proximal tubules after kidney damage and plays
an important role in inflammation and immune response. Research has
shown that the KIM-1 molecule, which is significantly synthesized in the
lung and kidney, can be a receptor that facilitates the binding of
SARS-CoV-2 to the cell surface through the IgV field and have put
forward that it may be the cause of acute kidney damage in patients with
Covid-19. Soluble urokinase plasminogen activator (suPAR), the dissolved
form of urokinase plasminogen activator, has been another molecule
thought to be responsible for acute kidney damage that may develop in
Covid-19. However, suPAR may also play a role in fetal complications
that may occur in the lungs and heart. suPAR plays an important role in
the remodeling of tissues under inflammation and immune cell migration
and activation.