Abbreviations
AA, arachidonic acid; ADD, afterdischarge duration; AC, adenylate cyclase; AEDs, anti-epileptic drugs; AGS, audiogenic seizure; ASP, Anticonvulsant Screening Program; cGMP, cyclic guanosine monophosphate; CNS, central nervous system; CREB, cAMP response element-binding; DAG, diacylglycerol; DBS: deep brain stimulation; DRE, drug-resistant epilepsy; EL, epilepsy like; ERK, extracellular signal-regulated kinase; GSK3β, glycogen synthase kinase 3β; HCN, hyperpolarization-activated cyclic nucleotide-gated; HDC, histidine-decarboxylase; HFS, high-frequency stimulation; HNMT, histamine N-methyltransferase; H1R, histamine H1 receptor; H2R, histamine H2 receptor; H3R, histamine H3 receptor; H4R, histamine H4 receptor; IP3, phosphatidyl inositol-4, 5-biphosphate; KA, Kainic acid; KM, Krushinski-Molodkina; KO, knock out; LFS, low-frequency stimulation; MAPK, mitogen-activated protein kinase; MES, maximal electroshock seizure; MTLE, mesial temporal lobe epilepsy; NINDS/NIH, National Institute of Neurological Disorders and Stroke/National Institutes of Health; PLA2, phospholipase A2; PKA, phosphokinase A; PKC, phosphokinase C; PTZ, pentylenetetrazole; RGC, retrosplenial granular cortex; STR, strychnine; TMN, tuberomammillary nucleus; VMAT-2, Vesicular monoamine transporter-2; WT, wide type