Results
The mean age of 24 patients (Male 13, Female 11) included in our study
was 38,3 (±25,7 SD) months. The mean macroscopic tumoral diameter was
9,1 (±3,8 SD) (Table 1). There was no significant difference between
both genders in terms of mean age (p: 0,11). Of the patients, 12 were
male and 11 were female, and the male to female ratio was 1.18. Of the
patients, 20 were triphasic, 2 were biphasic, and 2 were monophasic. Of
the patients, 8 had anaplasia findings, while 2 had nephrogenic
residues. When the local tumor spread sizes of the patients were
analyzed, of the patiens, 16 had renal pelvis invasion, 15 had renal
sinus soft tissue invasion, 8 had renal sinus lymphovascular invasion, 8
had renal vein invasion, 13 had renal capsular invasion, 9 had perirenal
adipose tissue invasion. Fifteen of the patients had lymphovascular
invasion. When the clinical stages of the patients were analyzed, it was
found that of the patients, 3 were Stage 1, 9 were Stage 2, 6 were Stage
3, 4 were Stage 4, and 2 were Stage 5. Of the patients, 4 had distant
organ metastasis and 4 had recurrence. Three of the patients died within
3 years.
When COX-2 expression was analyzed, of the patients, 1 showed no
expression, while 1 showed weakly positive cytoplasmic staining with
2-5%. These two patients were considered negative. All other patients
had COX-2 positivity of ≥10% of the tumoral area. In addition, there
was a weak expression of COX-2 in normal tubular structures.
There was no significant correlation between COX-2 positivity and renal
pelvis invasion (p: 0.31), renal sinus soft tissue invasion (p: 0.27),
renal sinus lymphovascular invasion (p: 0.31), renal vein invasion (p:
0.36), renal capsular invasion (p: 0.9), perirenal adipose tissue
invasion (p: 0.71), macroscopic tumor diameter (p: 0.76), presence of
anaplasia (p: 0.31), presence of nephrogenic residue (p: 0.67),
lymphovascular invasion (p: 0.27), clinical stage (p: 0.49), and
survival rate (p: 0.59).
In our study, the expression of COX-2 was observed especially in the
epithelial component, and the rates in the blastemal and epithelial
components were 3-5% and 60-70%, respectively (Figure 1-2). No
expression was observed in the mesenchymal component.