2.CD200-R inhibitors role in coronavirus infection:
Molecular studies indicated that some pathogens bypass the host cell’s
immune system by exploiting CD200: CD200-R signaling pathway. The animal
studies in mice showed that type 1 interferon (IFN 1) production in
response to TLR-7 signaling has a key role in coronavirus clearance, and
the CD200: CD200-R suppression prevents virus clearance by limiting IFN1
production (16). So, Using CD200
signaling inhibitors like Samalizumab in the early stages of Covid-19
infection might help restrict the virus invasion. Further clinical
studies are necessary to make a conclusion on CD200 inhibitors efficacy
in limiting specific viral infections as they are novel agents that
generally have not been involved in long term clinical trials, and
supportive details of using these agents are lacking.