Study outcomes
The primary composite outcome was maternal end-organ injury or death
arising between 20 weeks’ gestation and up to 42 days after the index
birth hospital discharge date. The list of conditions used to define
maternal end-organ injury was based on the CPM developed by
Bateman5 and validated by Metcalfe,6comprising 20 diagnoses and procedures, and consistent with Canadian
perinatal surveillance definitions for severe maternal morbidity and
death.17-19 (Table S1).
A secondary outcome was all-cause maternal mortality, from birth until
365 days postpartum, since previous work has shown a persistent increase
in mortality risk beyond the early postpartum
period.20,21