Conclusion
SNV that predispose to AF are also associated with discrete non-AF
phenotypes. Our observations underscore the biological complexity of the
AF genetics and its control of various aspects of cardiac development
and the autonomic nervous system. These findings highlight a potential
use for genetics at the intersection of atrial flutter and AF
management. Whether such traits represent true endophenotypes in AF is
not yet established, but they do support the general hypothesis that
more granular phenotyping will be necessary to realize the full
potential of human genetics in common disorders.
.