Conclusion
SNV that predispose to AF are also associated with discrete non-AF phenotypes. Our observations underscore the biological complexity of the AF genetics and its control of various aspects of cardiac development and the autonomic nervous system. These findings highlight a potential use for genetics at the intersection of atrial flutter and AF management. Whether such traits represent true endophenotypes in AF is not yet established, but they do support the general hypothesis that more granular phenotyping will be necessary to realize the full potential of human genetics in common disorders.
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