Post Atrial Flutter Ablation AF
The 78 subjects who underwent CTI without prior AF diagnosis consisted of patients in each of the GRS quartile [L, n=20, LI, n=19, HI, n=19, and H, n=20]. Baseline demographics were similar between the four quartiles labeled: age (L: 59 ± 6 years; LI: 55 ± 8 years; HI: 61 ± 5 years; H: 60 ± 7 years), male gender percent (L: 55%; LI: 53%; HI 58%; H: 60%); Body mass index (kg/m2) (L: 25.9 ± 4.7 ; LI: 28.1 ± 5.1; HI: 27.1 ± 4.4; H: 26.5 ± 6.5); hypertension (L: 15%; LI: 11%; HI 16%; H: 20%); diabetes (L: 15%; LI: 16%; HI 16%; H: 15%); coronary disease (L: 20%; LI: 16%; HI 11%; H: 20%); prior stroke (L: 10%; LI: 5%; HI 5%; H: 5%); ejection fraction (L: 55 ± 7 %; LI: 59 ± 8; HI: 61 ± 7; H: 62 ± 9) . Over an average of 2.4 years of follow up, 47 patients had documented AF. Figure 3 documents variable AF free survival post CTI ablation as stratified by AF genetic risk score (Log Rank Mantel-Cox test, p = 0.0004). At the end of follow up, 18 of the 20 high risk patients had documented AF while only 5 of the low risk.