Cardiac Conduction
Figure 2A shows cardiac conduction parameters observed as measured during an electrophysiologic study as stratified by AF GRS quartiles (n = L: 44; LI: 47; HI 45; H: 45). Baseline demographics were similar between the four quartiles labeled: age (L: 56 ± 10 years; LI: 55 ± 11years; HI: 56 ± 10 years; H: 57± 11 years), male gender percent (L: 50%; LI: 51%; HI 52%; H: 52%); Body mass index (kg/m2) (L: 26.9 ± 5.6 ; LI: 26.5 ± 6.6; HI: 26.4 ± 4.0; H: 27.0 ± 6.1); ejection fraction (L: 51 ± 0 %; LI: 52 ± 9; HI: 51 ± 8; H: 53 ± 9). There is no observed trend of HV (His-Ventricle) conduction time, QRS duration or QTc duration with increased AF GRS (QRS L: 102 ± 11 ms; LI: 103 ± 13 ms; HI: 99 ± 11 s; H: 105 ± 12 s; p = 0.11; HV L: 38 ± 9 ms; LI: 41 ± 8 ms; HI: 39 ± 9 s; H: 42 ± 11 s; p = 0.16; QTc L: 401 ± 24 ms; LI: 399 ± 27 ms; HI: 408 ± 30 s; H: 396 ± 26 s; p = 0.19). Figure 2B shows percent of total in each quartile of genetic risk with document dual AVN pathway. (L: 18%; LI: 23%; HI 42%; H: 67%; p< 0.01).