Correlation analysis of AD severity
Repeated measures correlation (R package: rmcorr) was applied to SCORAD
and log2-transformed serum protein concentration across all years to
account the dependent structure of the same patient over time for each
marker and Benjamini-Hochberg multiple comparison adjustment across
markers to report the correlation values and adjusted p -values
[12]. Volcano plots were used to identify significant correlations
(i.e., adjusted p -values <0.05 and repeated measures
correlation >0.3 or <-0.3).