Secondary outcomes
Secondary efficacy outcomes are as follows:
- Survival to day 28; Survival to day 60; and Survival to hospital discharge, censored at day 60
- Daily ratio of oxygen saturation by pulse oximetry to the fraction of inspired oxygen (SpO2/FiO2 ratio, highest and lowest levels)
- Daily change in modified ordinal score from baseline to day 14
- Number of patients showing worsening on the modified ordinal scale (see Table 1)
at 3, 7 and 14 days. Worsening is defined as an increase by at least 1 point among patients who had been receiving supplemental oxygen at baseline (modified ordinal scale 4 or 5) or at least 2 points among those who had not been receiving supplemental oxygen at baseline (modified ordinal scale 3).