With the advancement of epigenetic tools and technologies associated
with intervention medicine, stroke research has entered into a new
fertile, dynamic era of epigenetic studies, a wide plethora of
intervention procedure, administration of tissue plasminogen activator,
the introduction of mechanical thrombectomy, clinical studies, and drug
developments over the last decennium. Against this vivid background of
newly emerging pieces of knowledge, there is little to none advancement
in the overall outcome of the disease. The stroke involves an
overabundance of inflammatory responses arising in part due to the
body's immune response to brain injury. Neuroinflammation contributes to
significant neuronal cell death and the development of functional
impairment and death in stroke patients. Recent studies demonstrated
epigenetic plays a key role in the overall outcome of the disease. In
this review, we summarize the progress of epigenetics which provides an
overview of recent advancements on the emerging key role of epigenetics
over the last decade contributing to the regulation of neuroinflammation
in stroke, potential epigenetic targets that might be key factors in the
development of stroke therapies and their relation in respect to
clinical practice.