Effects of geohelminths on primary outcomes
Before adjustment for potential non-helminth confounders, both maternal
geohelminths and childhood geohelmiths were associated with a
significant reduction in SPT positivity, but not with wheeze or asthma
(Table 1). The univariate association of maternal helminths with atopy
(OR 0.69) was not attenuated by adjustment for non-helminth confounders
(OR 0.68, 95% CI 0.52-0.89, P=0.004) and remained little changed by
further adjustment for childhood geohelminths (OR 0.72, Table 2 and
Figure 2). The unadjusted association of childhood geohelminths with
atopy was of similar magnitude (OR 0.75) and was barely altered by
adjustment for non-helminth confounders (OR 0.77, 95% CI 0.59-1.01,
P=0.054) but became somewhat weaker with further adjusted for maternal
helminths (OR 0.82, Table 2 and Figure 2).