Effects of geohelminth infection chronicity and age of first infection on primary outcomes
Chronic exposures to childhood geohelminth infections were assessed as repeated infections in childhood (i.e., 0, 1, and >=2 documented infections with A. lumbricoides or T. trichiuraduring the first 5 years of life), and as cumulative burdens forA. lumbricoides or T. trichiura during the first 5 years of life. None of these had significant effects on outcomes (data not shown). Maternal geohelminths were strongly associated with childhood infections (adj. OR 2.70, 95% CI 2.23-3.22, P<0.001). To try and separate maternal/childhood geohelminth effects, we did a four-group analysis of combinations of maternal and childhood geohelminth infections (mother-/child-, mother+/child, mother-/child+, and mother+child+). Significant effects were observed on SPT for the mother+/child+ group (vs. mother-/child-, adj. OR 0.58, 95% CI 0.41-0.83, P=0.003).