Acknowledgement:
We are very grateful to the family participating in this study. This
work was supported by the Major Medical Collaboration and Innovation
Program of Guangzhou Science Technology and Innovation Commission
(201604020020), the National Natural Science Foundation of China
(81671067, 81974163, and 81701451), the China Postdoctoral Science
Foundation (2019M662852), the Natural Science Foundation of Guangdong
Province of China (2018A030313538), the Key-Area Research and
Development Program of Guangdong Province (2019B020227001) and the
German Research Foundation (DFG, SFB1315, FOR3004).