Author contribution:
H.H. conceived and coordinated the project. T.A.M., A.A.A. and A.M.K. recruited the cohort. N.L., P.Z., and M.M.Y. performed the zebrafish modeling. N.L. was in charge of the genetic analysis and bioinformatics with aids of N.K., X.F.. N.L., A.M.K. and H.H. wrote the manuscript with comments from all authors.