Acknowledgement:
We are very grateful to the family participating in this study. This work was supported by the Major Medical Collaboration and Innovation Program of Guangzhou Science Technology and Innovation Commission (201604020020), the National Natural Science Foundation of China (81671067, 81974163, and 81701451), the China Postdoctoral Science Foundation (2019M662852), the Natural Science Foundation of Guangdong Province of China (2018A030313538), the Key-Area Research and Development Program of Guangdong Province (2019B020227001) and the German Research Foundation (DFG, SFB1315, FOR3004).