References:
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1-     Wu JT, Leung K, Leung GM. Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study. Lancet. 2020;395(10225):689–697. doi: 10.1016/S0140-6736(20)30260-9. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
2-     Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020 doi: 10.1016/s2213-2600(20)30079-5. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
3-     Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–513. [PMC free article] [PubMed] [Google Scholar]
4-     Chung M, Bernheim A, Mei X, et al. CT imaging features of 2019 novel coronavirus (2019-nCoV). Radiology. 2020;295:202–207. [PMC free article] [PubMed] [Google Scholar]
5-     Khot WY, Nadkar MY. The 2019 Novel Coronavirus Outbreak–A Global Threat. J Assoc Physicians India. 2020;68(3):67. [PubMed] [Google Scholar]
6-     Eapen M.S., Sharma P., Moodley Y.P., Hansbro P.M., Sohal S.S. Dysfunctional Immunity and Microbial Adhesion Molecules in Smoking-Induced Pneumonia. Am. J. Respir. Crit. Care Med. 2019;199:250–251. doi: 10.1164/rccm.201808-1553LE. [PubMed] [CrossRef] [Google Scholar]
7-     Cai G. Bulk and single-cell transcriptomics identify tobacco-use disparity in lung gene expression of ACE2, the receptor of 2019-nCov. medRxiv. 2020:2020.02.05.20020107. doi:10.1101/2020.02.05.20020107 [CrossRef] [Google Scholar]
8-     Zhang H., Penninger J.M., Li Y., Zhong N., Slutsky A.S. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: Molecular mechanisms and potential therapeutic target. Intensive Care Med. 2020;46:586–590. doi: 10.1007/s00134-020-05985-9. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
9-     Kuba K., Imai Y., Rao S., Gao H., Guo F., Guan B., Huan Y., Yang P., Zhang Y., Deng W., et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat. Med. 2005;11:875–879. doi: 10.1038/nm1267. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
10-  Kunwei Li, Yijie Fang, Wenjuan Li ve ark.,(2020), CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19). Eur Radiol . 2020 Mar 25 : 1–10.doi: 10.1007/s00330-020-06817-6
11-  Huang C, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi: 10.1016/S0140-6736(20)30183-5. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
12-  Hoffmann M., Kleine-Weber H., Schroeder S., Kruger N., Herrler T., Erichsen S., Schiergens T.S., Herrler G., Wu N.H., Nitsche A., et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020 doi: 10.1016/j.cell.2020.02.052. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
13-  Jia H.P., Look D.C., Shi L., Hickey M., Pewe L., Netland J., Farzan M., Wohlford-Lenane C., Perlman S., McCray P.B., Jr. ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J. Virol. 2005;79:14614–14621. doi: 10.1128/JVI.79.23.14614-14621.2005. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
14-  Glowacka I., Bertram S., Herzog P., Pfefferle S., Steffen I., Muench M.O., Simmons G., Hofmann H., Kuri T., Weber F., et al. Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63. J. Virol. 2010;84:1198–1205. doi: 10.1128/JVI.01248-09. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
15-  Dijkman R., Jebbink M.F., Deijs M., Milewska A., Pyrc K., Buelow E., van der Bijl A., van der Hoek L. Replication-dependent downregulation of cellular angiotensin-converting enzyme 2 protein expression by human coronavirus NL63. J. Gen. Virol. 2012;93:1924–1929. doi: 10.1099/vir.0.043919-0. [PubMed] [CrossRef] [Google Scholar]
16-  Gurwitz D. Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics. Drug Dev. Res. 2020 doi: 10.1002/ddr.21656. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
17-  Deliana Kostova, Linda Andes. Cigarette Prices and Smoking Prevalence After a Tobacco Tax Increase — Turkey, 2008 and 2012
Figure-1: Box plots of alive and deceased groups for different variables
Figure-1: Box plots between alive and deceased groups for different variables