Clinical applicability of the study
The application of 24-hour MII-pH monitoring in patients with LPR could help improve the therapeutic response. Especially, the proximal all reflux time (≥45s) might play an important role to predict patients with LPR well responding to PPI therapy. Further studies on proximal parameters according to the reflux type in larger cohorts may help establish the cut-off value showing increased sensitivity and specificity to predict patients with LPR well responding to PPI therapy.