Clinical applicability of the study
The application of 24-hour MII-pH monitoring in patients with LPR could
help improve the therapeutic response. Especially, the proximal all
reflux time (≥45s) might play an important role to predict patients with
LPR well responding to PPI therapy. Further studies on proximal
parameters according to the reflux type in larger cohorts may help
establish the cut-off value showing increased sensitivity and
specificity to predict patients with LPR well responding to PPI therapy.