Background
Specific IgE against a peanut 2S albumin (Ara h2 or 6) is the best
predictor of clinically relevant peanut sensitization. However, sIgE
levels of peanut allergic and those of peanut sensitized but tolerant
patients partly overlap, highlighting the need for improved diagnostics
to prevent incorrect diagnosis and consequently unnecessary food
restrictions. Thus, we sought to explore differences in V(D)J gene
transcripts coding for peanut 2S albumin-specific monoclonal antibodies
(mAbs) from allergic and sensitized but tolerant donors