pADE-instances Number of pMDIs Number of pMDIs
All (% total)
Two or more (% total)
serotonin syndrome 384 (17.2) 191 (15.7)
seizure 319 (14.4) 236 (19.4)
QT 351 (15.8) 198 (16.3)
bleeding OR hemorrhage 319 (14.4) 205 (16.9)
nephrotoxic, renal failure 183 (8.2) 91 (7.5)
hepatotoxicity 112 (5.0) 55 (4.5)
bronchospasm 70 (3.2) 40 (3.3)
myopathy, rhabdomyolysis 74 (3.3) 34 (2.8)
sinus arrest 44 (2.0) 44 (3.6)
risk of infection 66 (3.0) 29 (2.4)
produce hypokalemia 82 (3.7) 21 (1.7)
bradycardia 70 (3.2) 27 (2.2)
ulceration 47 (2.2) 28 (2.3)
tendon rupture 36 (1.6) 13 (1.1)
AV block 16 (0.7) 2 (0.2)
reduced myocardial contractility 20 (0.9) 0 (0.0)
TOTALS 2222 1214