INTRODUCTION: The aim of this study investigated the effect of eosinophil and basophil counts on mortality in patients with COVID-19 infection. METHODS: Blood tests of 582 patients with RT-PCR test in an oropharyngeal swab sample who were admitted to Diyarbakır Gazi Yaşargil Training and Research Hospital between March 2020 and December 2020 were retrospectively analysed. The patients were divided into two groups: those who recovered and discharged and those who had a mortal course. Demographic data, comorbid diseases, routine blood tests, and haematological parameters were compared between both groups. RESULTS: An eosinophil count of 0.01 ± 0.04 and basophil count of 0.0261 ± 0.026 was observed in the patient group who had a mortal course at first admission to the hospital, while the eosinophil count was 0.06 ± 0.12 and basophil count was 0.020 ± 0.017 in the recovered patient group. On the fifth day after admission, the eosinophil count was 0.02 ± 0.07 and basophil count was 0.043 ± 0.042 in the patient group with a mortal course, while the count of eosinophils was 0.13 ± 0.14 and basophils was 0.023 ± 0.016 in the recovered patient group. In both groups, the eosinophil and basophil counts on the fifth day increased compared to the first day, and the eosinophil and basophil counts were lower in those who had a mortal course on both the first and fifth day (p < 0.05). CONCLUSIONS: In our study, a significant decrease was observed in the count of eosinophils and basophils in the mortal group of COVID-19 patients. Eosinopenia and basopenia may be parameters that can be used to facilitate the diagnosis of COVID-19, and the depth of both eosinopenia and basopenia is positively correlated with COVID-19 mortality.

McArdle disease (Glycogen storage disease type V, GSDV ) is an inherited disorder of glycogen metabolism affecting only skeletal muscles. A 56-year-old male patient with McArdle disease had the symptoms such as fatigue, muscle weakness since he was 8 years old in his history. A Pre-emptive kidney transplant from his wife was performed on the patient who has gone through rhabdomyolysis attacks during his life period. As far as known, this is the first case in the literature. We aim to share this process before and after the transplantation.

Abstract Objective: The purpose of this study is to investigate the relationship between microvascular dysfunction and the presence of fragmented QRS(f-QRS) in patients with acute inferior myocardial infarction(MI) who underwent primary percutaneous coronary intervention(PPCI). Methodology:274 consecutive patients with a mean age of 56.8 ± 9.8 who met the inclusion criteria were enrolled; patients with TIMI 2-3 flow after PPCI were divided into two groups according to the myocardial blush grade (MBG) 0-1 and MBG 2-3. The f-QRS includes different morphologies of the QRS and includes an additional R wave (R ’) or notching at the lowest end of the S wave in two adjacent leads releasing the infarct area. ECG records were taken to assess f-QRS and ST segment resolution was assessed in the first hour after the procedure. During angiographic examination, myocardial blush grade (MBG) and TIMI flow were measured in the right coronary artery due to post-procedure infarction. Results:The patients were divided into two groups as MBG 0-1 and MBG 2-3. In general, the median age was 56.8 ± 9.8,and 49 patients(17.9%) were women. Among all study patients, f-QRS count was 36(13.1%). In this study, 62 and 212 patients had MBG 0-1 and MBG 2-3, respectively. f-QRS was detected in 23(21.7%) patients in the MBG 0-1 group and 13(10.7%) patients in the MBG 2-3 group. In multivariate logistic regression, f-QRS [OR: 2.3(1.13-5.06),p = 0.027],ST segment resolution at first hour [OR: 0.62 (0.39-0.90),p = 0.04], and TIMI frame number [OR: 1.05(1.01-1.09),p = 0.004] were found to be associated with MBG 0-1. Conclusion:Our study showed that the presence of f-QRS after PPCI was associated with microvascular dysfunction in patients with inferior MI who underwent successful PPCI.F-QRS, a simple and inexpensive parameter, can be used to assess microvascular dysfunction in MI patients who underwent PPCI. Keywords:microvascular dysfunction,fragmented QRS,myocardial infarction