Interaction analysis between RB and MET protein
Based on data available in BioGRID and STRING databases, no direct
interaction between RB1 and MET proteins could be established. This is
supported by the different subcellular localizations of the wild-type
proteins, as RB1 and MET act in diverse subcellular compartments (in the
nucleoplasm and in the cytoplasm, respectively).
However, RB1 and MET share multiple interaction partners. Based on
BioGRID database, common interacting partners include CDK4, CDK6, GRB2,
MYC, and RAF1 proteins, as well. Thus, simultaneous functional changes
of RB1 and MET may basically transactivate the existing signaling
networks.