Patients’ characteristics
Retrospective analysis of 930 patients were delivered with FGR in the
obstetrics and gynecology hospital affiliated from January 1, 2014 to
December 30, 2019 at Women’s Hospital, School of Medicine, Zhejiang
University, in Hangzhou. We selected maternal features as follows: age,
pregnancy times, birth times, body mass index (BMI) before delivery,
weight gain during pregnancy, gestational week, delivery method,
hypertensive disorders of pregnancy(HDP), intrahepatic cholestasis of
pregnancy(ICP), gestational diabetes mellitus(GDM), hypothyroidism,
Placenta previa, thrombosis, anticardiolipin syndrome, abnormal cord
blood flow(absent or upside down), oligohydramnios, recurrent
spontaneous abortion (RSA), using prednisone, using aspirin, using low
molecular weight heparin. The following information of the offspring was
obtained: sex, fetal distress, admission to NICU. We selected
information about fetal distress diagnosed by obstetricians and
admission to NICU from the medical records of the hospital, as the
outcome of the study. The most widely adopted diagnostic criteria of
fetal FGR is an estimated fetal weight (EFW) below the 10th percentile
for the gestational age2. Exclusion criteria included
multiple pregnancies, cases of incomplete information. Among them, there
were 150 cases of fetal distress and 780 cases without fetal distress.
There were 478 cases of neonates entering into the NICU and 452 cases as
a control. Selecting 70% of the total cases randomly was for internal
validation (Figure 1A).