Graves’s diseases Graves’s diseases Graves’s diseases
Variables n PY IR cHR (95% CI) aHRꝉ (95% CI)
All
non-PCOS 170 160255 1.06 1.00 - 1.00 -
PCOS 59 40304 1.46 1.38 (1.03,1.86)* 1.34 (1.00,1.81)
Age, year
14-20 135 123609 1.09 1.00 - 1.00 -
21-50 83 66141 1.25 1.15 (0.87,1.51) 1.11 (0.85,1.46)
>50 11 10809 1.02 0.93 (0.50,1.72) 0.84 (0.45,1.57)
Comorbidities
asthma
No 219 192540 1.14 1.00 -
Yes 10 8019 1.25 1.10 (0.58,2.07)
anxiety
No 228 200085 1.14 1.00 -
Yes 1 473 2.11 1.85 (0.26,13.22)
CAD
No 224 199115 1.12 1.00 - 1.00 -
Yes 5 1444 3.46 3.08 (1.27,7.48)* 2.66 (1.08,6.56)*
cancer
No 229 200002 1.14 1.00 -
Yes 0 556 0.00 0.00 (0,Inf)
COPD
No 201 180104 1.12 1.00 -
Yes 28 20454 1.37 1.23 (0.83,1.82)
CHF
No 229 200242 1.14 1.00 -
Yes 0 317 0.00 0.00 (0,Inf)
CLD
No 214 188949 1.13 1.00 -
Yes 15 11610 1.29 1.14 (0.68,1.92)
diabetes
No 221 197572 1.12 1.00 - 1.00 -
Yes 8 2987 2.68 2.40 (1.18,4.85)* 2.17 (1.06,4.44)*
depression
No 214 192652 1.11 1.00 - 1.00 -
Yes 15 7906 1.90 1.71 (1.01,2.89)* 1.57 (0.92,2.67)
hypertension
No 225 197060 1.14 1.00 -
Yes 4 3499 1.14 1.00 (0.37,2.69)
hyperlipidemia
No 222 194455 1.14 1.00 -
Yes 7 6103 1.15 1.00 (0.47,2.13)
stroke
No 227 199223 1.14 1.00 -
Yes 2 1336 1.50 1.31 (0.33,5.27)
sleep apnea
No 229 200297 1.14 1.00 -
Yes 0 262 0.00 0.00 (0,Inf)
*: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression *: p-value<0.05; **: p-value<0.01; ***: p-value<0.001; PY: person-years; IR: incidence rate (per 1000 person-years); cHR: crude hazard ratio; aHR: adjusted hazard ratio; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CLD: chronic liver diseases; ꝉ: adjusted for age, CAD, diabetes and depression