WHAT IS KNOWN?
  1. PMN-MDSCs are involved in the progression of NSCLC by promoting tumor immune escape and metastasis.
  2. Initially, PMN-MDSCs shared similar morphology and phenotype with mature neutrophils, and the suppressive activity was the most reliable approach to identify PMN-MDSCs.
  3. LOX-1 is a newly confirmed maker for identifying PMN-MDSCs in human.