3.3.3. Efficacy Outcomes
The results of the pooled event rate come from 27 articles. 30- day mortality was 31.5% (95%CI of 0.149- 0. 482, (shown in Fig. 2A)), all patients were assessed for this outcome. 24 out of 27 articles(370/415),overall 415 patients were treated medically,and the successful device implantation rate was 89.7% (95%CI: 0.772- 1.021, (shown in Fig. 2B)). From 21 studies (274/370), we got the pooled event rate of immediate shunt reduction was 80.9% (95%CI: 0.645- 0.972, (shown in Fig. 2C)). Eighteen included articles (75/270) were assessed for the pooled event rate of 30-day mortality of primary closure at the acute phase, which was 25.3% (95%CI: 0.072-0.434, (shown in Fig. 2D)). Table 2 summarizes the original assessment results of single-arm studies.
On pairwise meta-analysis, no difference in 30-day mortality was identified (OR = 0.920 (95%CI: 0.420-2.013; p=0.252; (shown in Supplementary Fig. A)), no difference in immediate shunt reduction rate was identified (OR = 6.213 (95%CI: 2.085–18.511; p=0.092; (shown in Supplementary Fig. B)).