Sequence logo of untranslated region
The 5’ and 3’-untranslated region (UTR) were retrieved from each SARS-CoV-2 genome and aligned using MUSCLE v3.8.31 [20]. The conservation of UTR was visualized using WebLogo (http://weblogo.threeplusone.com/) and the second structure of 5’UTR was predicted using the RNAfold WebServer (http://rna.tbi.univie.ac.at/cgi-bin/RNAWebSuite/RNAfold.cgi) with the default parameters.