Appendectomy | Appendectomy | Appendectomy | Appendectomy | Appendectomy | Appendectomy | Compared to Control | Compared to Control | |
Yes | Yes | Yes | No | No | No | |||
Variables
|
Events
|
PY
|
Rate#
|
Events
|
PY
|
Rate#
|
Crude HR (95% CI) | Adjusted HR† (95% CI) |
All | 255 | 1737942 | 14.7 | 87 | 1766861 | 4.92 | 2.98(2.33, 3.79)*** | 2.78(2.17, 3.55)*** |
Ulcerative colitis (UC) |
116
|
6.67
|
49
|
2.77
|
2.40(1.72, 3.36)***
|
2.23(1.59, 3.12)***
|
||
Crohn’s disease (CD) |
139
|
8.00
|
38
|
2.15
|
3.71(2.59, 5.31)***
|
3.48(2.42, 4.99)***
|
||
Gender | ||||||||
Female | 119 | 851339 | 14.0 | 38 | 863289 | 4.40 | 3.17(2.20, 4.57)*** | 2.95(2.04, 4.26)*** |
Male | 136 | 886602 | 15.3 | 49 | 903572 | 5.42 | 2.82(2.04, 3.91)*** | 2.64(1.90, 3.67)*** |
Age, years | ||||||||
≤34 | 101 | 713152 | 14.2 | 29 | 704429 | 4.12 | 3.45(2.28, 5.21)*** | 3.33(2.20, 5.04)*** |
35-49 | 64 | 553971 | 11.6 | 13 | 560303 | 2.32 | 4.98(2.74, 9.03)*** | 4.63(2.54, 8.44)*** |
>50 | 90 | 470819 | 19.1 | 45 | 502128 | 8.96 | 2.13(1.49, 3.04)*** | 1.81(1.26, 2.60)** |
Comorbidity | ||||||||
No | 175 | 1466719 | 11.9 | 63 | 1628953 | 3.87 | 3.09(2.32, 4.12)*** | 3.12(2.34, 4.17)*** |
Yes | 80 | 271222 | 29.5 | 24 | 137908 | 17.4 | 1.69(1.07, 2.67)* | 1.75(1.11, 2.77)* |
Rate#: incidence rate per 10 000 person-years; Crude HR: relative hazard ratio; Adjusted HR†: adjusted hazard ratio after control for age, sex, and comorbidities of CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, and biliary stone; Comorbidity§: patients with CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, or biliary stone were classified as the comorbidity group. CAD, coronary artery disease; CI, confidence interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular disease; PY, person years; SD, standard deviation *P < .05, **P < .01, ***P < .001 | Rate#: incidence rate per 10 000 person-years; Crude HR: relative hazard ratio; Adjusted HR†: adjusted hazard ratio after control for age, sex, and comorbidities of CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, and biliary stone; Comorbidity§: patients with CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, or biliary stone were classified as the comorbidity group. CAD, coronary artery disease; CI, confidence interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular disease; PY, person years; SD, standard deviation *P < .05, **P < .01, ***P < .001 | Rate#: incidence rate per 10 000 person-years; Crude HR: relative hazard ratio; Adjusted HR†: adjusted hazard ratio after control for age, sex, and comorbidities of CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, and biliary stone; Comorbidity§: patients with CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, or biliary stone were classified as the comorbidity group. CAD, coronary artery disease; CI, confidence interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular disease; PY, person years; SD, standard deviation *P < .05, **P < .01, ***P < .001 | Rate#: incidence rate per 10 000 person-years; Crude HR: relative hazard ratio; Adjusted HR†: adjusted hazard ratio after control for age, sex, and comorbidities of CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, and biliary stone; Comorbidity§: patients with CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, or biliary stone were classified as the comorbidity group. CAD, coronary artery disease; CI, confidence interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular disease; PY, person years; SD, standard deviation *P < .05, **P < .01, ***P < .001 | Rate#: incidence rate per 10 000 person-years; Crude HR: relative hazard ratio; Adjusted HR†: adjusted hazard ratio after control for age, sex, and comorbidities of CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, and biliary stone; Comorbidity§: patients with CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, or biliary stone were classified as the comorbidity group. CAD, coronary artery disease; CI, confidence interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular disease; PY, person years; SD, standard deviation *P < .05, **P < .01, ***P < .001 | Rate#: incidence rate per 10 000 person-years; Crude HR: relative hazard ratio; Adjusted HR†: adjusted hazard ratio after control for age, sex, and comorbidities of CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, and biliary stone; Comorbidity§: patients with CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, or biliary stone were classified as the comorbidity group. CAD, coronary artery disease; CI, confidence interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular disease; PY, person years; SD, standard deviation *P < .05, **P < .01, ***P < .001 | Rate#: incidence rate per 10 000 person-years; Crude HR: relative hazard ratio; Adjusted HR†: adjusted hazard ratio after control for age, sex, and comorbidities of CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, and biliary stone; Comorbidity§: patients with CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, or biliary stone were classified as the comorbidity group. CAD, coronary artery disease; CI, confidence interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular disease; PY, person years; SD, standard deviation *P < .05, **P < .01, ***P < .001 | Rate#: incidence rate per 10 000 person-years; Crude HR: relative hazard ratio; Adjusted HR†: adjusted hazard ratio after control for age, sex, and comorbidities of CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, and biliary stone; Comorbidity§: patients with CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, or biliary stone were classified as the comorbidity group. CAD, coronary artery disease; CI, confidence interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular disease; PY, person years; SD, standard deviation *P < .05, **P < .01, ***P < .001 | Rate#: incidence rate per 10 000 person-years; Crude HR: relative hazard ratio; Adjusted HR†: adjusted hazard ratio after control for age, sex, and comorbidities of CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, and biliary stone; Comorbidity§: patients with CAD, hypertension, diabetes, hyperlipidemia, CVA, heart failure, COPD, CKD, alcohol-related diseases, cirrhosis, or biliary stone were classified as the comorbidity group. CAD, coronary artery disease; CI, confidence interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular disease; PY, person years; SD, standard deviation *P < .05, **P < .01, ***P < .001 |