Acknowledgement
This study is supported in part by Taiwan Ministry of Health and Welfare
Clinical Trial Center (MOHW109-TDU-B-212-114004). The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
Ethics approval : This study obtained approval from the
Institutional Review Board of China Medical University Hospital
(CMUH-104-REC2-115), Taiwan.
Authors’ contributions: Conception and design: Wei-Sheng Chung;
Administrative support: Wei-Sheng Chung and all authors; Collection and
assembly of data: All authors; Data analysis and interpretation: all
authors; Manuscript writing: All authors. Final approval of manuscript:
All authors
References
1. Tannoury J, Abboud B. Treatment options of inflammatory appendiceal
masses in adults. World journal of gastroenterology.2013;19(25):3942-3950.
2. Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of
appendicitis and appendectomy in the United States. American
journal of epidemiology. 1990;132(5):910-925.
3. Lin KB, Chan CL, Yang NP, et al. Epidemiology of appendicitis and
appendectomy for the low-income population in Taiwan, 2003-2011.BMC gastroenterology. 2015;15:18.
4. Vitetta L, Chen J, Clarke S. The vermiform appendix: an immunological
organ sustaining a microbiome inoculum. Clinical science (London,
England : 1979). 2019;133(1):1-8.
5. Kooij IA, Sahami S, Meijer SL, Buskens CJ, Te Velde AA. The
immunology of the vermiform appendix: a review of the literature.Clinical and experimental immunology. 2016;186(1):1-9.
6. Randal Bollinger R, Barbas AS, Bush EL, Lin SS, Parker W. Biofilms in
the large bowel suggest an apparent function of the human vermiform
appendix. J Theor Biol. 2007;249(4):826-831.
7. Im GY, Modayil RJ, Lin CT, et al. The appendix may protect against
Clostridium difficile recurrence. Clin Gastroenterol Hepatol.2011;9(12):1072-1077.
8. Kuenzig ME, Benchimol EI, Lee L, et al. The Impact of Inflammatory
Bowel Disease in Canada 2018: Direct Costs and Health Services
Utilization. J Can Assoc Gastroenterol. 2019;2(Suppl 1):S17-s33.
9. Kim YS, Jung SA, Lee KM, et al. Impact of inflammatory bowel disease
on daily life: an online survey by the Korean Association for the Study
of Intestinal Diseases. Intest Res. 2017;15(3):338-344.
10. Yen HH, Weng MT, Tung CC, et al. Epidemiological trend in
inflammatory bowel disease in Taiwan from 2001 to 2015: a nationwide
populationbased study. Intest Res. 2019;17(1):54-62.
11. Ramos GP, Papadakis KA. Mechanisms of Disease: Inflammatory Bowel
Diseases. Mayo Clin Proc. 2019;94(1):155-165.
12. Frisch M, Johansen C, Mellemkjaer L, et al. Appendectomy and
subsequent risk of inflammatory bowel diseases. Surgery.2001;130(1):36-43.
13. Gardenbroek TJ, Eshuis EJ, Ponsioen CI, Ubbink DT, D’Haens GR,
Bemelman WA. The effect of appendectomy on the course of ulcerative
colitis: a systematic review. Colorectal Dis. 2012;14(5):545-553.
14. Andersson RE, Olaison G, Tysk C, Ekbom A. Appendectomy is followed
by increased risk of Crohn’s’s disease. Gastroenterology.2003;124(1):40-46.
15. Frisch M, Gridley G. Appendectomy in adulthood and the risk of
inflammatory bowel diseases. Scandinavian journal of
gastroenterology. 2002;37(10):1175-1177.
16. Andersson RE, Olaison G, Tysk C, Ekbom A. Appendectomy and
protection against ulcerative colitis. The New England journal of
medicine. 2001;344(11):808-814.
17. Chen D, Ma J, Luo S, Lu L, Wan X, Ben Q. Effects of Appendectomy on
the Onset and Course of Ulcerative Colitis in Chinese Patients.Gastroenterol Res Pract. 2018;2018:2927891.
18. Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence
of inflammatory bowel disease in the 21st century: a systematic review
of population-based studies. Lancet (London, England).2018;390(10114):2769-2778.
19. Ng SC, Bernstein CN, Vatn MH, et al. Geographical variability and
environmental risk factors in inflammatory bowel disease. Gut.2013;62(4):630-649.
20. Turpin W, Goethel A, Bedrani L, Croitoru Mdcm K. Determinants of IBD
Heritability: Genes, Bugs, and More. Inflammatory bowel diseases.2018;24(6):1133-1148.
21. Liu JZ, Anderson CA. Genetic studies of Crohn’s’s disease: past,
present and future. Best practice & research Clinical
gastroenterology. 2014;28(3):373-386.
22. Krautkramer KA, Kreznar JH, Romano KA, et al. Diet-Microbiota
Interactions Mediate Global Epigenetic Programming in Multiple Host
Tissues. Molecular cell. 2016;64(5):982-992.
23. Sartor RB, Wu GD. Roles for Intestinal Bacteria, Viruses, and Fungi
in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic
Approaches. Gastroenterology. 2017;152(2):327-339.e324.
24. Castro F, de Souza HSP. Dietary Composition and Effects in
Inflammatory Bowel Disease. 2019;11(6).
25. Pan WH, Wu HJ, Yeh CJ, et al. Diet and health trends in Taiwan:
comparison of two nutrition and health surveys from 1993-1996 and
2005-2008. Asia Pacific journal of clinical nutrition.2011;20(2):238-250.
26. Guinane CM, Tadrous A, Fouhy F, et al. Microbial composition of
human appendices from patients following appendectomy. mBio.2013;4(1).
27. Kundu P, Blacher E, Elinav E, Pettersson S. Our Gut Microbiome: The
Evolving Inner Self. Cell. 2017;171(7):1481-1493.
28. Dasso JF, Howell MD. Neonatal appendectomy impairs mucosal immunity
in rabbits. Cellular immunology. 1997;182(1):29-37.
29. Zuo T, Ng SC. The Gut Microbiota in the Pathogenesis and
Therapeutics of Inflammatory Bowel Disease. Frontiers in
microbiology. 2018;9:2247.
30. Abegunde AT, Muhammad BH, Bhatti O, Ali T. Environmental risk
factors for inflammatory bowel diseases: Evidence based literature
review. World journal of gastroenterology. 2016;22(27):6296-6317.
31. Beigrezaei S, Ghiasvand R, Feizi A, Iraj B. Relationship between
Dietary Patterns and Incidence of Type 2 Diabetes. Int J Prev
Med. 2019;10:122.
32. Wang D, He Y, Li Y, et al. Dietary patterns and hypertension among
Chinese adults: a nationally representative cross-sectional study.BMC Public Health. 2011;11:925.