5. Conclusions
Taken together, in this study, we gained sight into the biochemical
mechanisms of OCD from the activity of the neopterin–BH4 pathway and
changes in inflammatory and oxidative parameters. Circulating TGF-1β and
BH4 levels were significantly lower in the OCD group compared to the
healthy control group, whereas neopterin and NO levels were
significantly higher. Based on these findings, we postulate that the
levels of TGF-1β and NO and the activation of the neopterin–BH4 pathway
may be involved in the pathophysiology of OCD. This study not only
provides insight into the mechanisms underlying OCD but also presents
novel opportunities for the design and development of more effective
therapeutic strategies.