Legend
Figure 1. Dose–response relationship for the
anti-nociceptive effect of s.c. Exoticin evaluated by hot plate in WT
mice. (A-F) Time course of hot plate antinociception of different dose
Exoticin given subcutaneously in WT mice. Groups of mice were given
different doses of Exoticin by subcutaneously and tested for analgesic
response at different time points. (G)The cumulative dose–response
curves were performed on groups of WT mice for antinociception in the
hot plate assay with Exoticin subcutaneously. Animals were tested 15 min
after the Exoticin to generate the analgesic response curve. Each point
in graphs represents mean ± SEM maximum possible effect (%MPE). Sample
sizes are 6 mice per dose, Dotted lines indicate 50%MPE.