Abstract
Backgroundand
Purpose: Mu-opioids remain vastly important for pain treatment, and
would represent ideal analgesics if their analgesic effects could be
separated from their many side effects.
Exoticin,
an extract of Murraya exotica , has been shown to have an
analgesic effect which can be blocked by naloxone. Here, we hypothesized
that the analgesic effect of Exoticin is mediated by 6-transmembrane
(6TM) of the mu-opioid receptor.