Abstract
Backgroundand Purpose: Mu-opioids remain vastly important for pain treatment, and would represent ideal analgesics if their analgesic effects could be separated from their many side effects. Exoticin, an extract of Murraya exotica , has been shown to have an analgesic effect which can be blocked by naloxone. Here, we hypothesized that the analgesic effect of Exoticin is mediated by 6-transmembrane (6TM) of the mu-opioid receptor.