sociated with cancer including management of side
effects caused by opioids. Opioids couple opioid receptors and affect
several pharmacological effects. In addition to analgesic effects,
opioids have side effects such as constipation, nausea and vomiting, and
respiratory depression. Mu receptor agonists have been used to control
pain and treat side effects caused by opioids, and are even clinically
used in an opioid withdrawal syndrome. Our experimental results prove
that Exoticin, as a new chemotype for opioid analgesia which does not
have opioid-related side effects.
In summary, the 6TM MOR-1 splice variant mMOR-1G is both necessary and
sufficient for Exoticin analgesia. With its broad analgesic activity in
thermal, inflammatory, and mechanical pain models[33], as well as
its lack of side effect such as respiratory depression, physical
dependence, and so on, Exoticin may represent a new class of analgesic
different from traditional opioids and 6TM variants may be an valuable
targets or direction for future analgesic drug development.