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Figure 1. Dose–response relationship for the anti-nociceptive effect of s.c. Exoticin evaluated by hot plate in WT mice. (A-F) Time course of hot plate antinociception of different dose Exoticin given subcutaneously in WT mice. Groups of mice were given different doses of Exoticin by subcutaneously and tested for analgesic response at different time points. (G)The cumulative dose–response curves were performed on groups of WT mice for antinociception in the hot plate assay with Exoticin subcutaneously. Animals were tested 15 min after the Exoticin to generate the analgesic response curve. Each point in graphs represents mean ± SEM maximum possible effect (%MPE). Sample sizes are 6 mice per dose, Dotted lines indicate 50%MPE.