Figure 2. Antinociception of Exoticin in (A) formalin test and (B, C) CFA inflammatory pain test. Mice pre-administrated with Exoticin, spontaneous pain behavior was observed immediately in WT and E1/E11 mice following injection 5% formalin(A). Symbols in graphs on left represent mean ± standard error of the mean (SEM) percent samples licking (*P < 0.05, #P<0.05). Animals received a s.c. injection of Exoticin or vehicle at 4 days after CFA injection in WT and E1/E11 mice, followed by hot plate (B) and mechanical (C) withdrawal assay. Symbols in graphs on left side represent mean ± SEM maximum possible effect (%MPE) or withdraw force (*P < 0.05, compared with baseline,#P<0.05 compared with E1/E11 KO + Exoticin group). Sample sizes are 6 to 8 mice per group.