Affiliations:
College of Veterinary Medicine, South China Agricultural University,
Guangzhou, China;
Institute of Animal Health, Guangdong Academy of Agricultural
Sciences, Scientific Observation and Experiment Station of Veterinary
Drugs and Diagnostic Techniques of Guangdong Province, Ministry of
Agriculture of Rural Affairs, and Key Laboratory of Animal Disease
Prevention of Guangdong Province, Guangzhou, 510640, China.
Address for correspondence:
Shao-Lun Zhai, Animal Disease Diagnostic Center, Institute of Animal
Health, Guangdong Academy of Agricultural Sciences, Guangzhou, 510640,
China, zhaishaolun@163.com; Dong-Sheng He, College of Veterinary
Medicine, South China Agricultural University, Guangzhou, 510642, China,
dhe@scau.edu.cn.
Abstract: Seneca Valley virus (SVV) is an emerging
picornavirus, which mainly affects swine health. However, previous
studies showed that mice could be infected by SVV. In addition, the
antibodies against SVV were detected in bovine blood. The data reveal
the possible cross-species transmission of SVV. In this study, one SVV
strain (SVA/GD/China/2018) was first isolated from a buffalo farm in
Guangdong, China, using seven mammalian cell lines. Compared with the 35
reference SVV strains, sequence analysis showed that SVA/GD/China/2018
shared 93.4%–99.1% and 97.5%–99.4% similarity in complete genome
level and polyprotein gene level, respectively. Interestingly,
SVA/GD/China/2018 shared the highest nucleotide similarity (99.1%) with
one wild boar strain (Sichuan HS-01). Genetic analysis revealed that
SVA/GD/China/2018 clustered with the porcine-origin SVV strains.
Isolation of SVV in buffalo further supported potential cross-species
transmission of SVV.
Keywords: Seneca Valley virus; porcine; buffalo; cross-species
transmission