Introduction
Despite treatment options with antifungal drugs and surgery,Aspergillus mediastinitis is generally fatal, particularly in
immunocompromised patients following orthotopic heart transplantation
(OHT), [1, 2]. Herein, we describe the seven-year follow-up of a
patient with early postoperative invasive Aspergillus fumigatusinfection, referred to us with sternal dehiscence after OHT.
Conventional surgical debridement and intravenous antifungal treatment
were thought to be hopeless due to the degree of Aspergillusdissemination, which may carry a 90-100% mortality in immunosuppressed
patients. [1, 3] An innovative combination of surgical and topical
antifungal treatment eventually cured the patient, allowing him to
return to normal life. As this is neither a clinical trial nor an
observational study, no Institutional Review Board was required. The
patient gave consent for the publication of this report.