Data Collection and Statistical Analysis
Data were collected and stored electronically, in accordance with HIPAA and in a de-identified format, using a registry identification number as an identifier. Data were analyzed using a statistical software package (R 3.6.3) with the assistance from the Department of Pediatrics and Biostatistics. Continuous variables were presented as median and interquartile range (IQR) and categorical variables were presented as frequency and percentage. EACA and TXA patients were compared using Wilcoxon rank sum test for continuous variables and Chi-square test for categorical variables. Ordinal logistic regression model was used to find the transfusion factors that associate with intraoperative and postoperative blood loss adjusting for age, weight, operative time, surgical vault category (anterior / fronto-orbital advancement, mid-posterior, or total), and syndromic status.