Comparative pulmonary disease evolution of TB & T2D/TB
Mice fed with hypercaloric diet for three weeks old and treated at eight
weeks old with only one low dose of streptozotocin showed progressive
weight increase (Fig. 1B), and after two months showed significant
higher sera concentration of glucose, triglycerides, cholesterol and
insulin (Fig. 1C, D, E, and F). The histology study of the liver showed
extensive lipid cytoplasmic vacuolization of hepatocytes (steatosis)
(Fig. 1H). Treatment of these mice with metformin or glibenclamide
resulted in normal blood concentrations of glucose (Fig. 1G). Thus,
these mice showed the metabolic parameters of T2D.
In comparison with chow fed mice infected with Mtb, infected T2D mice
showed significant higher pulmonary bacilli burdens (Fig. 2A). T2D/TB
mice also showed lower expression of TNF-α and decreasing survival rate
than TB mice (Fig. 2B, and 2C). Thus, T2D/TB mice suffered more severe
disease than TB mice.