Figure. 2. Comparative course of pulmonary tuberculosis in diabetic (T2D-TB) and non-diabetic (TB) mice. A) Five mice per group were sacrificed at the indicated time points (14, 21, 28, and 120 post-infection) and the right lungs were used to determine the bacterial loads by counting colony-forming units (CFU). A significant increase in the bacillary load of the T2D-TB group was observed after one and four months of infection in comparison with the TB group. B) The comparative survival rate of both groups. C) Comparative expression of TNFα determined by RT-PCR in the lungs of T2D/TB and TB groups, there is significant lower expression after 120 days of infection in the former group. Asterisk represent statistical significance p<0.05.