Figure 1.- Metabolic abnormalities and liver pathology of mice with type 2 diabetes mellitus model vs non-diabetic animals (control).A) General description of the experimental groups. B) mice were weighted weekly to monitor the weight gain induced by the hypercaloric diet. Data are presented as a mean and standard derivation of 5 mice per group for 16 weeks. C) Blood glucose levels were assessed two and four weeks after administration of STZ intraperitoneally in animals fed with a high-caloric diet treated with streptozotocin (HFD-STZ) and in animals not treated with STZ and fed with Chow control diet. Concentrations in sera of C) triglyceride, D) cholesterol, and E) insulin in control and T2D groups, after four months of feeding with hyper caloric diet and one month of STZ treatment. G) Effect of hypoglycemic drugs on the control of serum glucose levels in T2D animals, before and after 8 and 24 hours of oral administration of metformin (Met) or glibenclamide (Gly), arrows indicate administration times (0, 8 and 24 hours). Asterisk represents statistical significance (one-way ANOVA, P <0.05, and two-way ANOVA for graph 1 B, 1 C, and 1 G).H) Representative micrograph of liver tissue from a control mouse (left figure) and extensive cytoplasmic vacuolization of hepatocytes corresponding to steatosis in T2D mouse (right figure).