Figure Legends
Figure 1. The flowchart of our prospective study
A total of 520 patients diagnosed with KD were initially screened for participation in this study. Of these, patients who had received initial IVIG treatment at other medical facilities (n=87), received IVIG treatment within 10 days of fever onset (n=12), or cases where IVIG treatment was initiated before blood sampling (n=17) were excluded. Another 19 patients were excluded because of incomplete laboratory data or lack of follow-up results. Finally, data from 385 patients were analyzed. Of the 385 patients, 326 (84.7%) responded to initial IVIG treatment, whereas 59 (15.3%) did not respond. Of the 59 patients with initial IVIG resistance, 23 did not respond to repeated IVIG treatment and received pulse intravenous methylprednisolone infusion. Then data analysis and multivariate logistic regression analysis were performed in these groups.
Figure 2. The receiver-operating characteristic (ROC) curve for coagulation profiles in predicting initial and repeated IVIG resistance. (A) ROC curve for coagulation profiles (PT, APTT, D-dimer, ATIII) in predicting initial IVIG resistance. (B) ROC curve for ATIII in predicting repeated IVIG resistance.
Supplemental material 1 . Comparison of coagulation profiles between the groups of CALs and non-CALs group in KD
Supplemental material 2 . Clinical correlation between univariate factors and coagulation profile in the KD subjects