Patient and oral immunotherapy characteristics
Baseline patient characteristics are reported in Table 1. For patients with CM allergy, the initial OIT dose was >66 mg CM protein in 26 (60%) patients; <66 mg in 15 (35%) patients; and unknown in two patients. For patients with wheat allergy, the initial OIT dose was >52 mg wheat protein in 11 (35%) patients; <52 mg in 16 (52%) patients; and unknown in four patients. In total, four (9%) CM allergy patients and five (16%) wheat allergy patients experienced anaphylaxis by the programed intake of the allergens during OIT without exercise. Of them, one patient with a CM allergy required an adrenaline injection. Among the CM allergy patients, 5% achieved desensitization with a full dose by 1 year, 35% by 2 years, and 60% by 3 years after the start of OIT. Among the wheat allergy patients, 17% achieved desensitization with a full dose by 1 year, 42% by 2 years, and 79% by 3 years after the start of OIT. The rest took more than 3 years to reach the full dose.