KEY RESULTS
CS exposure was associated with a reduction in HDAC-2 activity and the
up-regulation of ROS expression. PTX, ROF and THEO administration led to
the partial restoration of HDAC-2 activity, however combining TRI to any
of these PDEIs did not synergistically augment this effect. The
restoration of HDAC-2 activity was favorably associated with the
reduction of ROS expression.