Study design
In order to compare the effects of THEO, PTX and ROF when used alone and in combination with a GC, the mice were randomly divided into nine groups (n = 10 for each group): (1) Sham CS exposure; (2) CS exposure; (3) CS exposure with ROF administration; (4) CS exposure with PTX administration; (5) CS exposure with THEO administration; (6) CS exposure with triamcinolone (TRI) administration; (7) CS exposure with co-administration of ROF and TRI; (8) CS exposure with co-administration of PTX and TRI; (9) CS exposure with co-administration of THEO and TRI. The course set for CS exposure was 30 weeks and the medication intervention started at the 29th week of the course and continued for 2weeks.