As expected, emphysema-like structural damage was observed in mice with
long-term CS -exposure (Figure 2, panel A), and was associated with a
greater Lm compared to the sham CS exposure group (52.70
±
0.31
μm in CS exposed vs. 32.39 ± 3.55 μm in sham CS exposed, P< 0.05). Two weeks of’-treatment with either THEO, PTX, ROF or
the addition of TRI with any of these PDEIs, did not mitigate the
structural damage (Figure 2, panel A and B, P >
0.05).