Pro-inflammatory cytokines in BALF
Long term CS exposure induced the up-regulation of TNF-α (Figure 3, panel A) and IL-8 (Figure 3, panel B) in BALF. Only PTX was able to down-regulate the expression of TNF-α (P < 0.05), and the addition of TRI did not improve this inhibitory. PTX, THEO and TRI resulted in the down-regulation of IL-8 expression (P < 0.05), and the addition of TRI intensifies this inhibition (P< 0.05), not only when used with PTX and THEO but also when used with ROF.