Study design
In order to compare the effects of THEO, PTX and ROF when used alone and
in combination with a GC, the mice were randomly divided into nine
groups (n = 10 for each group): (1) Sham CS exposure; (2) CS
exposure; (3) CS exposure with ROF administration; (4) CS exposure with
PTX administration; (5) CS exposure with THEO administration; (6) CS
exposure with triamcinolone (TRI) administration;
(7) CS exposure with co-administration of ROF and TRI; (8) CS exposure
with co-administration of PTX and TRI; (9) CS exposure with
co-administration of THEO and TRI. The course set for CS exposure was 30
weeks and the medication intervention started at the
29th week of the course and continued for 2weeks.