Statistical Analysis
Statistical analyses were performed using Graphpad Prism software 5.0 (GraphPad Software Inc., La Jolla, California). Data were first tested for normal distribution. Parametric (such as ANOVA and post hocDunnett’s comparisons) and non-parametric (such as Kruskal-Wallis test) statistics were applied where appropriate. Stepwise regression was applied to the pooled data, exploring the variables which were relevant to the decline of HDAC-2 activity. P < 0.05 was regarded as statistically significant.