Pulmonary Morphology and Morphometry
As expected, emphysema-like structural damage was observed in mice with long-term CS -exposure (Figure 2, panel A), and was associated with a greater Lm compared to the sham CS exposure group (52.70 ± 0.31 μm in CS exposed vs. 32.39 ± 3.55 μm in sham CS exposed, P< 0.05). Two weeks of’-treatment with either THEO, PTX, ROF or the addition of TRI with any of these PDEIs, did not mitigate the structural damage (Figure 2, panel A and B, P > 0.05).