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Comparative analysis of the diagnostic value of several methods for the diagnosis of patent foramen ovale
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  • Fangfang Liu,
  • Qingyu Kong,
  • Xiaojun Zhang,
  • Yan Li,
  • Shimin Liang,
  • Shuang Han,
  • Guishuang Li
Fangfang Liu
Shandong University Qilu Hospital
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Qingyu Kong
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Xiaojun Zhang
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Shimin Liang
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Shuang Han
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Guishuang Li
Shandong University Qilu Hospital
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Objective: The aim of this research was to compare the sensitivity and positive predictive value of contrast transcranial Doppler (c-TCD), contrast- transthoracic echocardiography (c-TTE) and contrast- transesophageal echocardiography (c-TEE), to determine the best method for diagnosing patent foramen ovale (PFO) and to provide a reference for the further improvement of clinical practice. Methods: We investigated 161 patients who suffered from migraines, cryptogenic stroke, TIA, and cerebral infarction of unknown cause. All patients underwent transcatheter examination, and the results of the right heart catheterization (RHC) were considered the gold standard for PFO diagnosis. Results: The present study revealed that c-TTE with the Valsalva maneuver had a higher sensitivity in detecting PFO related right-to-left shunt (PFO-RLS), but it might have a higher rate of misdetection than c-TCD. Conclusion: Patients with suspected PFO can be examined with c-TCD first, and if positive results are obtained, then c-TTE and c-TEE should be performed for further confirmation.

Peer review status:ACCEPTED

17 Oct 2020Submitted to Echocardiography
17 Oct 2020Submission Checks Completed
17 Oct 2020Assigned to Editor
19 Oct 2020Reviewer(s) Assigned
22 Nov 2020Review(s) Completed, Editorial Evaluation Pending
23 Nov 2020Editorial Decision: Revise Major
05 Dec 20201st Revision Received
08 Dec 2020Assigned to Editor
08 Dec 2020Submission Checks Completed
08 Dec 2020Reviewer(s) Assigned
12 Jan 2021Review(s) Completed, Editorial Evaluation Pending
19 Jan 2021Editorial Decision: Revise Major
26 Jan 20212nd Revision Received
26 Jan 2021Submission Checks Completed
26 Jan 2021Assigned to Editor
26 Jan 2021Reviewer(s) Assigned
15 Mar 2021Review(s) Completed, Editorial Evaluation Pending
21 Mar 2021Editorial Decision: Revise Minor
29 Mar 20213rd Revision Received
29 Mar 2021Submission Checks Completed
29 Mar 2021Assigned to Editor
05 Apr 2021Review(s) Completed, Editorial Evaluation Pending
06 Apr 2021Editorial Decision: Accept