Conclusions
In a retrospective study of a large clinical database, we evaluated concurrent efficient acute and chronic inflammatory conditions. Our study showed a significant decrease in the concurrence of inflammatory disease with increasing age, suggesting a possible mutual exclusivity between the two inflammatory states. Further immunological studies are necessary to understand this mechanism. Meanwhile, it may be beneficial to reconsider the treatment of acute inflammatory conditions in the population to minimize the burden of chronic inflammatory disease.
Funding : None
Conflict of interest: The authors declare there are no conflicts of interest.
Ethical clearance: Not applicable (secondary data from clinical records)
Consent for participation: Not applicable
Consent for publication: Not applicable
Availability of data and materials: from Mendeley: http://dx.doi.org/10.17632/c7zyt694f2.1
Authors’ contributions: SM and MM analysed the data for the retrospective study from the large clinical database. SM, MM, VV, VS, ES, NK, DC, DT, LJ and AJ were the primary physicians who treated, analysed and provided the data for the 21 additional cases presented here. SM wrote the manuscript and did the referencing. GV is the guarantor and guide of this study. All authors have read the final version and approved the manuscript.
The poster of this study was presented at the ‘Movementis’ conference in TelAviv, Israel in July 2019.
Acknowledgements: The authors thank Anjum Warsi, Amritha Belagaje and Pooja Dhamodar for technical assistance.