Conclusions
In a retrospective study of a large clinical database, we evaluated
concurrent efficient acute and chronic inflammatory conditions. Our
study showed a significant decrease in the concurrence of inflammatory
disease with increasing age, suggesting a possible mutual exclusivity
between the two inflammatory states. Further immunological studies are
necessary to understand this mechanism. Meanwhile, it may be beneficial
to reconsider the treatment of acute inflammatory conditions in the
population to minimize the burden of chronic inflammatory disease.
Funding : None
Conflict of interest: The authors declare there are no
conflicts of interest.
Ethical clearance: Not applicable (secondary data from clinical
records)
Consent for participation: Not applicable
Consent for publication: Not applicable
Availability of data and materials: from Mendeley:
http://dx.doi.org/10.17632/c7zyt694f2.1
Authors’ contributions: SM and MM analysed the data for the
retrospective study from the large clinical database. SM, MM, VV, VS,
ES, NK, DC, DT, LJ and AJ were the primary physicians who treated,
analysed and provided the data for the 21 additional cases presented
here. SM wrote the manuscript and did the referencing. GV is the
guarantor and guide of this study. All authors have read the final
version and approved the manuscript.
The poster of this study was presented at the ‘Movementis’ conference in
TelAviv, Israel in July 2019.
Acknowledgements: The authors thank Anjum Warsi, Amritha
Belagaje and Pooja Dhamodar for technical assistance.