INTRODUCTION
Quantification of left ventricular size and function from echocardiography is important in the diagnosis, prognosis, and management of pediatric heart disease.1 With rapid improvement in technology, three-dimensional echocardiography (3DE) evaluation of left ventricular (LV) volume and function in pediatrics compares favorably with magnetic resonance imaging (MRI)2-5. However, a multicenter trial to generate normative 3DE z-scores in a large pediatric population would be desirable for clinical use.
A multicenter trial would provide important information regarding 3DE LV volumes and function in children of various ages and sizes. Such a large-scale study would also allow for generation of normative data in pediatric patients. Thus, the aim of this study is to establish normal z-score values in this unique population using 3DE volumes and function in a multicenter trial.