Conclusion
AML-M2 was the dominant morphology in AE-AML. The incidence of EML and c-KIT mutations were much higher in adult patients and adversely affected the disease outcome in this group of patients, suggesting AML1-ETO fusion gene might behave differently in adults and children. While the intensive induction and consolidation therapy were considered to benefit patients of AE-AML regardless of age, their use have not improved the prognosis of adult patients either presenting with EML or harboring a c-KIT mutation. Studies are required in the future to explore the underlying pathogenesis of EML and c-KIT mutation in pediatric and adult AE-AML.