Diagnosis and classification
The morphology of bone marrow and peripheral blood was reviewed
following Wright-Giemsa staining and classified according to the
French-American-British (FAB) classification. Immunophenotype was
analyzed by flow cytometry. The cytogenetics was established by
chromosome banding combined with fluorescence in situ hybridization
(FISH) [7]. The diagnosis of AE-AML was made based on WHO 2016
classification [10]. EML included extramedullary infiltration (EMI)
and central central nervous system leukemia (CNSL), which was defined
according to the previous report by Støve HK et al [11].