CNS Diseases Reagents Functions
Ischemic stroke
Extract of Naotaifang (Lan et al., 2020)
Regulating TFR1/DMT1 and SCL7A11/GPX4 pathways
Carvacrol (Guan et al., 2019) Increasing the expression of GPX4
Tat-linked SelP Peptide (Alim et al., 2019) Upregulating the expression of GPX4
Intracerebral hemorrhage stroke DFO (Okauchi et al., 2010) Chelating iron
Fer-1 (Li et al., 2017) Trapping free radicals
Parkinson’s disease Ferric ammonium citrate (FAC) (Zhang et al., 2020) Upgrading ferritin levels
Fer-1 (Do Van et al., 2016) Trapping free radicals
Deferiprone (Martin-Bastida et al., 2017) Chelating iron
Alzheimer’s disease Lip-1 (Hambright et al., 2017) Trapping free radicals
Deferiprone (Rao et al., 2020) Chelating iron
Huntington’s disease DFO (Chen et al., 2013) Chelating iron
Fer-1 and its analogues (Skouta et al., 2014) Trapping free radicals