FIGURE 3. A cartoon illustrating a VLP
nanoparticle-based vaccine against peanut allergy. The nanoparticles
are packed with ssRNA, a TLR7/8 ligand, and display Ara h2 antigen. The
natural pentameric IgM antibody can bind the VLPs with low affinity/high
avidity. Such interaction contributes to the activation of classical
complement cascade and binding of the formed immune-complex on FDCs for
effective formation of GCs. This vaccine may induce high-affinity
antibodies, drive antibody class-switching and establish long-lived
memory. Abs; antibodies.