Figure Legends
Figure 1. Histological and immunostaining finding on two NB genotype–phenotype discordant cases. Representative images of Case 1 (A–C) and Case 2 (D–F) are shown. (A ) Hematoxylin and eosin (H&E) staining: status after chemotherapy, equivalent to favorable histology (FH) of the International Neuroblastoma Pathology Classification (INPC); Neuroblastoma (Schwannian stroma-poor), poorly differentiated subtype with “conventional” type nuclei. (B ) Fluorescence in situ hybridization (FISH):MYCN -amplification was detected (Vysis LSI N-MYC (2p24) Spectrum Green/ CEP 2 Spectrum Orange Probe). (C ) Immunohistochemical staining for N-myc was negative. (D ) H&E: FH of INPC; Neuroblastoma (Schwannian stroma-poor), poorly differentiated subtype with “conventional” type nuclei. (E ) Not all, but some cells showed more than 4-fold increase in MYCN signal compared toCEP2 . (F ) Immunohistochemical staining for N-myc was negative.