Study eligibility criteria:
PICOS (Patient/Population, Intervention, Comparison, Outcome, Study
types) framework was used as inclusion criteria for this systematic
review and meta-analysis. Original investigations with randomized
controlled trial design that conducted among postmenopausal women were
considered for inclusion in this article. For inclusion, trials should
report the effects of soy isoflavones or soy isoflavones plus soy
protein on serum concentration of CRP as primary or secondary outcomes.
After reading the full texts of retrieved clinical trials, we did not
consider RCTs with following criteria in our systematic review and
meta-analysis: 1) taking other nutrient supplements beside soy in
intervention group; 2) trials without comparison group; 3) Not reporting
information related to serum concentration of CRP at baseline or after
intervention and any data for computing it; 4) Reporting serum
concentration of CRP in figures; 5) Not reporting the dose of soy
isoflavones and protein in natural soy product; 6) Non-English articles.