Literature search:
Literature search was conducted by searching PubMed (http://www.pubmed.com; National Library of Medicine), Scopus (http://www.scopus.com/), and ISI Web of Science (http://www.thomsonreuters.com), Cochrane Library (https://www.cochranelibrary.com), and Clinicaltrials.gov (https://www.clinicaltrials.gov) up to January 2020 to identify RCTs exploring the effect of soy isoflavones, soy protein or combination on CRP levels among postmenopausal women. Those data bases were searched by following related medical subject heading (MeSH) terms and non-MeSH terms for soy, CRP and clinical trial: “C-Reactive Protein”, “Protein-C Reactive”, “CRP”, “Soy Foods”, “Soy Food”, “Soy, Food”, “Soy, Foods”, “Soyfood”, “Soyfoods”, “Foods Soy”, “Soy Cheese”, “Soy Cheeses”, “Soy Sauce”, “Soysauce”, “Soy Bean Curd”, “Texturized Soy Protein”, “Texturized Soy Proteins”, “Texturized Vegetable Protein”, “Soya”, “Natto”, “Tempeh”, “Tofu”, “Miso”, “Soy Milk”, “Milk Soy”, “Milk, Soy”, “Soy Beverage”, “Soy Beverages”, “Soy, Beverage”, “Soybeans”, “Soybean”, “Soy Bean”, “Soy Beans”, “Glycine max”, “Soybean Proteins”, “Soy Bean Proteins”, “Soy Protein”, “Soy Proteins”, “Proteins Soy”, “Protein Soy”, “Genistein”, “Soy Products”, “Isoflavones”, “Isoflavone”, “Homoisoflavones”, “3-Benzylchroman-4-Ones”, “Phytoestrogens”, “Phytoestrogen”, “Phyto-Estrogen”, “Plant Estrogen”, “Plant Estrogens”, “Equol”, “Clinical Trials”, “Clinical Trial”, “RTC”. Search strategy was designed by Boolean operators, quotation marks, parentheses, and asterisks. All found papers by systematic search were exported to reference manager software (EndNote X7) and two reviewers separately checked title and abstract of exported papers in order to find relevant RCTs. Reference list of relevant reviews and RCTs were hand searched to find any other relevant RCTs. We did not have any restriction on publication time and any discrepancies were solved by consulting with third investigators (A.Gho).