Cheng et al. 2016 (32)
|
Metanalysis
|
N/A
|
Metanalysis cross-sectional and case-controlled studies
|
OME and AR are prevalent in pre-school and school-aged children. The
study suggests allergy is a risk factor for OME.
|
Yes
(Level I)
|
Gultekin et al. 2004
(33)
|
Epidemiologic study
|
N=1800 school-children
|
To determine the impact of environmental, epidemiologic and familial
factors in the development of persistent OME
|
Allergy history was a statistically significant factor among children
with OME compared to normal children.
|
Yes
(Level IV)
|
Kreiner-Møller 2012
(34)
|
Cohort study.
|
N= 291 children (6yr)
|
To investigate the association between atopic disease and OME.
|
OME was diagnosed in 39% of the cohort and was associated with AR
(OR = 3.36, CI = 1.26-8.96, P = 0.02).
|
Yes
(Level III)
|
Kwon et al. 2013
(35)
|
Case-control study
|
N=370 children with OME and 100 controls
|
To assess the relationship between OME and allergic diseases
|
The incidence of AR alone was significantly higher in children with OME
(33.8%) than without OME (16.0%);
|
Yes
(Level III)
|
Sharifian et al. 2019
(36)
|
Case-control study
|
N=37 OME children and 52 controls (2-15 years)
|
To investigate immunoglobulin E (IgE) mediated hypersensitivity as a
causative factor in the development of OME.
|
Allergic rhinitis prevalence was notably higher among OME patients than
in the control group; there were no differences in eosinophil counts,
serum IgE concentrations and nasal smear eosinophils in the two
groups.
|
Yes
(Level III)
no correlation with biomarkers
|
Roditi et al. 2015
(37)
|
Retrospective analysis
|
N=133 (<18 years)
|
To determine whether there is a significant relationship between
allergic rhinitis and OME and whether age is an effect modifier of any
such association
|
Age is an effect modifier of the association between allergic rhinitis
and OME; a significant relationship is observed in children 6 years of
age and older, whereas there is no significant association in younger
children.
|
Yes
(Level IV)
|
Torretta et al 2018 (39)
|
Retrospective study
|
N=153 (59.4± 16.4months)
|
A retrospective chart review evaluating the effect of allergy in the
development of recurrent AOM with or without OME.
|
Higher prevalence of allergy or atopy in children with RAOM with OME
than in those without OME
|
Yes
(Level IV)
|
Quaranta et al. 2013
(40)
|
Epidemiologic study
|
N=81 children, Mean age 6.9 yr.
|
To evaluate the role of the different forms of chronic rhinitis in the
pathogenesis OME in children with AH.
|
70% of children had a chronic rhinitis with AH and 60% of them had
OME. Nasal cytology together with Skin prick test showed that AR was
rarely present in this group.
|
Yes
(Level IV)
|
Norhafizh et al. 2020 (41)
|
Prospective cross-sectional study.
|
N=130 children (4-18 years)
|
To determine the preva-
lence of allergic rhinitis in children with persistent OME
|
High prevalence of allergic
rhinitis in children with persistent OME (80.3%); dust mites was the
most common allergen.There was a statistically significant improvement
of the hearing threshold after anti-allergy therapy.
|
Yes
(Level II)
|
Songu et al. 2020 (42)
|
Cohort study.
|
N=539 patients undergoing surgery for AH
|
To determine the most important risk factors in the development of OME
in children with adenoid hypertrophy.
|
Atopy and allergic rhinitis resulted as main risk factors for OME.
|
Yes
(Level III)
|