Search strategy
This systematic review was conducted in accordance with the Preferred
Reporting Items for Systematic Review and Meta-Analysis (PRISMA) process
to identify published experimental and clinical articles about allergy
and otitis media in children. Manuscript were screened primarily by Ovid
Medline and EMBASE and from other sources (Pubmed Central, Cochrane
review, Web of Science, and Google Scholar) and published from January
2000 to September 2020. Literature searches were performed in September
2020.
We performed two different searches using MeSH-terms. One group of
authors focused on experimental studies matching the term as
follow: [(Eustachian tube disfunction) OR (middle ear cytokine) OR
(middle ear inflammation)] AND [(allergy) OR (allergic rhinitis) OR
(atopy) OR (atopic) OR (allergic children)] AND [(children) OR
(childhood) OR (pediatric)]. The second group of authors focused onclinical studies, matching the term as follow: [(acute otitis
media) OR (chronic otitis media) OR (otitis media with effusion) OR
(recurrent acute otitis media) OR (middle ear effusion) OR (chronic
suppurative otitis media) OR (otitis)] AND [(allergy) OR (allergic
rhinitis) OR (atopy) OR (atopic) OR (allergic children) OR (non-allergic
children) OR (immunoglobulin E) OR (immunotherapy) OR (antihistamine)
AND (children) OR (childhood) OR (pediatric)].