Figure Legends
Figure 1 Study protocol. AF, atrial fibrillation; CRT, cardiac
resynchronization therapy; ECG, electrocardiography; ECGI,
electrocardiographic imaging; FOI, fusion-optimized intervals; LVEF,
left ventricular ejection fraction; MPP, multipoint pacing; NYHA, New
York Heart Association; SPP, single-point pacing.
Figure 2 Box plot showing the ΔQRS duration (QRS shortening
compared with baseline QRS) at each of the three pacing configurations:
SPP-FOI, MPP, and SPP-FOI+MPP. The median ΔQRS duration is indicated by
the black line inside the box. FOI, fusion-optimized intervals; MPP,
multipoint pacing; SPP, single-point pacing.
Figure 3 Programming at discharge with the shortest possible
QRS duration. FOI, fusion-optimized intervals; MPP, multipoint pacing.
Figure 4 ECGI during the biventricular activation sequence in a
patient with left bundle branch block. The upper panel represents an
anterior view; the inferior panel represents a posterior view. At
baseline, cardiac activation starts from the RV, but in pacing
configurations, cardiac activation changes to simultaneous RV-LV. FOI,
fusion-optimized intervals; LV, left ventricle; MPP, multipoint pacing;
RV, right ventricle; SPP, single-point pacing.
Figure 5 Biventricular activation times using
electrocardiographic imaging showing no significant differences among
the 3 groups. Box plot showing the Δ biventricular activation time
(shortening compared with baseline) at each of the three pacing
configurations: FOI, MPP, and FOI+MPP. The median activation time
is indicated by the black line inside the box. FOI, fusion-optimized
intervals; MPP, multipoint pacing; SPP, single-point pacing.
Figure 6 Scatter plot showing a positive linear correlation
between the paced-QRS duration (via electrocardiography) and
biventricular activation time (measured by ECGI) at each pacing
configuration: FOI, MPP, and FOI+MPP. FOI, fusion-optimized intervals;
MPP, multipoint pacing.