Left ventricular remodeling:
MR was abolished in all patients immediately following TMVI and this was
associated with a reduction in LV volumes. At 3-months no patient had
>1+MR (n=46; p<0.001 vs baseline) (Table 5;
Figure 4). Thirty-six patients (78%) had a LVEF <50% at
baseline, and 18 patients (39%) had a LVEF
≤35%. For the entire group,
indexed LVEDV (LVEDVI) and indexed LVESV (LVESVI) were elevated
pre-operatively (88±24mL/m² and 54±20mL/m² respectively) (Tables 2 and
3), and decreased on discharge to 72±23mL/m² (p=0.001) and 45±17mL/m²
(p=0.03), respectively (Table 5; Figure 5). The improvement in LVEDVI
was sustained at 3-month follow-up (70±40 mL/m², p=0.003), but was
associated with a small decline in LVEF (40±10% vs 36±15%; p=0.008)
(Table 5). There was a non-significant decline in LVGLS, whilst
circumferential and radial strain remained steady at 3-months presumably
due to the effect of the apical tether (Table 5).