Bivariate and multivariate risk for mortality or ICU admission
In the bivariate analysis the following variables were associated with the composite end-point mortality or ICU admission (Table 1, 2 and 3 ): advanced age, more comorbidities (specially diabetes mellitus, cardiovascular and respiratory chronic diseases), higher PROFUND score at baseline, anticoagulant prescription before admission, respiratory insufficiency and radiographic abnormalities on admission, more prominent laboratory abnormalities (elevated levels of creatinine, C-reactive protein, procalcitonin, creatine kinase, aspartate aminotransferase and lactate dehydrogenase), requiring higher oxygen concentrations (or prone positioning) and no receiving medical treatment. In the multivariate adjusted analysis only two variables persisted as a significant risk factor for the composite endpoint: a higher PROFUND score punctuation (OR 1.4; 95% CI: 1.1-1.8) and higher C-reactive protein values on admission (OR 1.2; 95%CI: 1.1-1.4).