Bivariate and multivariate risk for mortality or ICU admission
In the bivariate analysis the following variables were associated with
the composite end-point mortality or ICU admission (Table 1, 2
and 3 ): advanced age, more comorbidities (specially diabetes mellitus,
cardiovascular and respiratory chronic diseases), higher PROFUND score
at baseline, anticoagulant prescription before admission, respiratory
insufficiency and radiographic abnormalities on admission, more
prominent laboratory abnormalities (elevated levels of creatinine,
C-reactive protein, procalcitonin, creatine kinase, aspartate
aminotransferase and lactate dehydrogenase), requiring higher oxygen
concentrations (or prone positioning) and no receiving medical
treatment. In the multivariate adjusted analysis only two variables
persisted as a significant risk factor for the composite endpoint: a
higher PROFUND score punctuation (OR 1.4; 95% CI: 1.1-1.8) and higher
C-reactive protein values on admission (OR 1.2; 95%CI: 1.1-1.4).